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Supplements

Every supplements product on YourProtocol, graded on evidence and tied to the protocols that call for it.

Life Extension

Strong ~$8

Life Extension Melatonin 300mcg, the low-dose form some sleep protocols specifically call for; brand-level testing, not per-lot certified.

Called for in Beat Jet Lag
YourProtocol
Buy

Thorne

Strong ~$19

Thorne Glycine, NSF Certified for Sport with per-lot testing; sold as capsules rather than the bulk powder some protocols call for, so…

Called for in The Sleep Toolkit
Andrew Huberman
Buy

Double Wood

Strong ~$20

Double Wood Apigenin 50mg; evidence is still emerging, so treat this as an early-stage pick. Brand-level testing, not per-lot certified.

Called for in The Sleep Toolkit
Andrew Huberman
Buy

Nutricost

Strong ~$20

Nutricost Beta-Alanine Powder, an unflavored bulk powder at a low per-serving cost; brand-level testing, not per-lot certified.

Called for in Endurance & VO2 Max
Andy Galpin
Buy

Thorne Theanine 200mg

Strong ~$24

A standalone 200mg dose, the amount in the sleep and focus literature, from a brand with a consistent public testing program.

Andrew Huberman, Mark Hyman
Buy

Life Extension Super Bio-Curcumin (BCM-95)

Strong ~$25

Uses BCM-95 enhanced-absorption curcumin shown to outperform a curcumin plus piperine blend for absorption, satisfying the…

Gary Brecka, YourProtocol
Buy

Thorne Magnesium Bisglycinate (powder)

Strong ~$32

For a general magnesium slot, glycinate is the best-evidenced form for sleep and relaxation; same NSF Certified for Sport pick as the…

Thomas DeLauer, Gabrielle Lyon, Casey Means
Buy

Life Extension Neuro-Mag (Magtein)

Strong ~$32

Patented Magtein L-threonate, the one magnesium form shown to raise brain magnesium in the cited cognition research, distinct from…

Andrew Huberman, Mark Hyman
Buy

Nordic Naturals Ultimate Omega

Strong ~$32

High EPA and DHA per serving and the most independently batch-tested fish oil in the category (IFOS 5-star), which is fish-oil-specific…

Bryan Johnson, Sara Gottfried, Mark Hyman
Buy

Momentous Recovery Grass-Fed Whey Isolate

Strong ~$45

Pure whey isolate, double-certified (NSF Certified for Sport and Informed Sport), a stronger tier than the better-known Isopure, which…

Layne Norton
Buy

Timeline

Strong ~$100

Timeline Mitopure, the best-evidenced urolithin A product of this group though notably more costly than the others; brand-level testing,…

Gabrielle Lyon
Buy

Beta-alanine + citrulline

Strong
Andy Galpin

Caffeine / pre-workout

Strong
Layne Norton

Citrulline malate / beta-alanine

Strong
Layne Norton

Decaf coffee

Strong
Called for in Caffeine & Sleep
Matthew Walker

Fibre / fermented foods

Strong
Tim Spector

Handheld lactate meter

Strong
Called for in Zone 2 Endurance Base
Peter Attia

High-EPA fish oil

Strong
Called for in Evidence-Based Fat Loss
Layne Norton

Vitamin C serum + mineral sunscreen

Strong
Bryan Johnson

Vitamin D3 / omega-3

Strong
Layne Norton

Life Extension

Moderate ~$8

Life Extension Melatonin 3mg, an established brand with brand-level testing (not per-lot certified).

Bryan Johnson
Buy

NOW

Moderate ~$9

NOW Boron 3mg, a simple accurate dose from a long-standing brand with brand-level testing (not per-lot certified).

Andrew Huberman
Buy

NOW

Moderate ~$11

NOW Chromium Picolinate 200mcg, the chelated form most protocols specify, from a brand with brand-level testing (not per-lot certified).

Mark Hyman
Buy

NOW

Moderate ~$11

NOW L-Tyrosine 500mg, a straightforward single-ingredient dose from a long-standing value brand with brand-level testing (not per-lot…

Andrew Huberman
Buy

Life Extension

Moderate ~$12

Life Extension Zinc Lozenges, an established brand pick in lozenge form; brand-level testing, not per-lot certified.

Called for in Everyday Immune Support
YourProtocol
Buy

Thorne

Moderate ~$13

Thorne Iron Bisglycinate 25mg, NSF Certified for Sport with per-lot testing and the bisglycinate form chosen for better tolerability than…

Stacy Sims
Buy

NOW Foods Psyllium Husk Powder

Moderate ~$13

Soluble psyllium husk, the fiber form with the strongest IBS and cholesterol evidence, from a reliable value brand that is Non-GMO Verified…

Called for in The Good Energy Plate
Casey Means
Buy

Nutricost

Moderate ~$16

Nutricost Tart Cherry Extract, a concentrated single-ingredient capsule from a value brand; brand-level testing, not per-lot certified.

YourProtocol
Buy

NOW

Moderate ~$16

NOW Vitamin C-1000 Sustained Release with Rose Hips, a long-standing brand pick; brand-level testing, not per-lot certified.

Gary Brecka
Buy

Nutricost KSM-66 Ashwagandha 600mg

Moderate ~$17

The clinically-studied KSM-66 extract, not generic root powder, with BioPerine for absorption, from a reliable value brand.

Kyle Gillett, Sara Gottfried, YourProtocol
Buy

Jarrow Formulas Alpha Lipoic Sustain 300mg

Moderate ~$18

Correct sustained-release ALA form from a long-standing brand with facility-level cGMP and stated lab testing.

Tim Ferriss, Mark Hyman
Buy

Thorne Vitamin D-5,000

Moderate ~$18

Standalone D3 with full NSF Certified for Sport; confirm the 5,000 IU dose against each protocol, lower-IU NSF variants exist.

Mark Hyman, YourProtocol
Buy

NOW Foods Berberine HCl 500mg

Moderate ~$20

The straight berberine HCl form the evidence uses; NOW ran independent HPLC testing where 30 of 33 Amazon berberines failed potency and…

Mark Hyman, David Sinclair
Buy

NOW

Moderate ~$20

NOW EGCg Green Tea Extract 400mg, the standardized-EGCg form protocols specify, from a brand with brand-level testing (not per-lot…

Called for in Slow-Carb Fat Loss
Tim Ferriss
Buy

NOW Foods Phosphatidyl Serine 100mg

Moderate ~$20

A standard 100mg dose of the soy-derived form used in the cognitive research, from a long-standing value brand.

Andrew Huberman, Sara Gottfried
Buy

Sports Research Vitamin D3 + K2 (MK-7)

Moderate ~$20

K2 is MK-7, the form the evidence supports; the more famous Thorne D and K2 uses MK-4 and fails that requirement.

Dom D'Agostino, Gabrielle Lyon, Louisa Nicola
Buy

Bulletproof Brain Octane C8 MCT Oil

Moderate ~$25

Pure C8 caprylic only, not a C8 and C10 blend, from the brand that created and still leads the category with transparent coconut-only…

Dave Asprey, Thomas DeLauer
Buy

Double Wood

Moderate ~$25

Double Wood Tongkat Ali 200:1 extract, a concentrated ratio at a reasonable price; brand-level testing, not per-lot certified.

Andrew Huberman
Buy

Doctor's Best

Moderate ~$27

Doctor's Best High Absorption CoQ10 100mg, a widely used GMP-manufactured option; no third-party certification published.

Rhonda Patrick
Buy

Kasandrinos Organic Extra Virgin Olive Oil

Moderate ~$28

Single-estate, first cold-pressed current-harvest Greek EVOO, USDA Organic, with polyphenol content stated on the label. Polyphenol levels…

Mary Claire Haver, Mark Hyman, Bryan Johnson
Buy

Thorne Basic Nutrients 2/Day

Moderate ~$30

A comprehensive daily multi in bioavailable forms, NSF Certified for Sport, same brand family as our creatine and magnesium picks.

Mark Hyman, Rhonda Patrick
Buy

Thorne Magnesium Bisglycinate (powder)

Moderate ~$32

Correct chelated bisglycinate form (not oxide), NSF Certified for Sport, and a powder so the dose titrates for sleep protocols.

Sara Gottfried, Mark Hyman, Sean O'Mara
Buy

Thorne Broccoli Seed Extract

Moderate ~$35

Broccoli seed extract standardized to sulforaphane glucosinolate (50mg SGS), the active compound, from a brand with a consistent testing…

Rhonda Patrick
Buy

Nordic Naturals

Moderate ~$40

Nordic Naturals Algae Omega, a vegan EPA/DHA source from a brand with per-lot third-party testing across its omega line; kept separate from…

Called for in The Omega-3 Protocol
Rhonda Patrick
Buy

Nordic Naturals EPA (High EPA)

Moderate ~$40

An EPA-predominant formula (the form with the ADHD and mood evidence, an adjunct that supports focus, not a treatment) that is third-party…

Called for in ADHD & Focus Toolkit
Andrew Huberman
Buy

Aged garlic extract + policosanol

Moderate
Called for in Slow-Carb Fat Loss
Tim Ferriss

Blackout curtains

Moderate
Paul Saladino

Blood ketone meter

Moderate
Dom D'Agostino

Broad-spectrum sunscreen

Moderate
Called for in Skin From The Inside Out
YourProtocol

Caffeine / coffee

Moderate
Called for in Recover From Lost Sleep
YourProtocol

Cinnamon extract

Moderate
Mark Hyman

Compression boots / sleeves

Moderate
YourProtocol

Exogenous ketone supplement

Moderate
Dom D'Agostino

Fish oil / algae oil

Moderate
Gary Brecka

Floating water thermometer

Moderate
Called for in Deliberate Cold Exposure
Andrew Huberman

Gratitude journal

Moderate
Called for in Build Everyday Happiness
YourProtocol

HEPA air purifier

Moderate
Paul Saladino

Iron

Moderate
Stacy Sims

Magnesium / B-complex

Moderate
Sara Gottfried

Magnesium glycinate / L-theanine

Moderate
Called for in Calm the Stress Response
YourProtocol

Omega-3 + vitamin D3 & K2

Moderate
Thomas DeLauer, Mary Claire Haver

Omega-3 / vitamin D

Moderate
Called for in Build Everyday Happiness
YourProtocol

Plain cottage cheese

Moderate
Stuart Phillips

Retinol / retinoid

Moderate
Called for in Skin From The Inside Out
YourProtocol

Slow-release caffeine

Moderate
Bryan Johnson

Third-party-tested fish oil

Moderate
Called for in The Omega-3 Protocol
Rhonda Patrick

Vitamin C serum + moisturiser

Moderate
Called for in Skin From The Inside Out
YourProtocol

Vitamin C serum + SPF

Moderate
Gary Brecka

Vitamin D3 + zinc

Moderate
Kyle Gillett

Vitamin D3 + zinc + magnesium

Moderate
Peter Attia

Walking shoes / gym basics

Moderate
Called for in Build Everyday Happiness
YourProtocol

Warm socks

Moderate
Called for in Temperature & Your Sleep
Matthew Walker

Yerba mate or coffee

Moderate
Called for in Huberman AM Protocol
Andrew Huberman

Zinc + vitamin D3

Moderate
Andrew Huberman

NOW

Limited ~$10

NOW TMG (Trimethylglycine) 1000mg; evidence for some claimed uses is still emerging. Brand-level testing, not per-lot certified.

Gary Brecka
Buy

NOW

Limited ~$18

NOW DIM 200 with Calcium D-Glucarate, a standard paired formulation from a long-standing brand; brand-level testing, not per-lot certified.

Called for in Hormone Balance Protocol
Sara Gottfried
Buy

Double Wood

Limited ~$20

Double Wood Resveratrol 500mg, a straightforward single-ingredient dose; brand-level testing, not per-lot certified.

David Sinclair
Buy

Thorne B-Complex #6

Limited ~$22

Active methylated B forms (5-MTHF folate, methylcobalamin), not the cheaper cyano and folic-acid forms, NSF Certified for Sport.

Gary Brecka, Mark Hyman
Buy

Double Wood

Limited ~$23

Double Wood Fisetin 100mg; evidence here is early/preclinical, so treat this as an emerging pick rather than a settled one. Brand-level…

Bryan Johnson
Buy

Doctor's Best

Limited ~$25

Doctor's Best PepZin GI, the zinc-carnosine (PepZin GI) form specifically studied for gut lining support; GMP-manufactured, no third-party…

Called for in Functional Gut Reset
Mark Hyman
Buy

Sports Research

Limited ~$26

Sports Research D3 5000IU, a widely reviewed pick in oil-based softgels for absorption; brand-level testing, not per-lot certified.

Rhonda Patrick
Buy

Codeage

Limited ~$34

Codeage Liposomal Glutathione 1000mg, a liposomal delivery form for better absorption; GMP-manufactured, no third-party certification…

Mark Hyman
Buy

Doctor's Best

Limited ~$34

Doctor's Best Kaneka Ubiquinol 100mg, the reduced (active) CoQ10 form using the reference Kaneka raw material; GMP-manufactured, no…

Mark Hyman
Buy

Momentous Rhodiola Rosea

Limited ~$35

NSF Certified for Sport rhodiola; the plain alternative could not be confirmed certified.

Sara Gottfried, Mark Hyman
Buy

ProHealth

Limited ~$40

ProHealth Ca-AKG 1000mg; evidence here is early/preclinical, so treat this as an emerging pick. Brand-level testing, not per-lot certified.

Bryan Johnson
Buy

Thorne

Limited ~$43

Thorne Quercetin Phytosome, NSF Certified for Sport with per-lot testing and a phytosome delivery form for better absorption than plain…

Mark Hyman
Buy

Enzymedica Digest Gold + ATPro

Limited ~$45

A broad-spectrum enzyme blend, not single-enzyme, the most-recommended brand in the category with a long track record.

Mark Hyman
Buy

Thorne

Limited ~$45

Thorne Curcumin Phytosome (Meriva), NSF Certified for Sport with per-lot testing and the Meriva phytosome form shown to improve absorption…

Mark Hyman
Buy

Double Wood

Limited ~$45

Double Wood Spermidine 10mg; evidence is still emerging, so treat this as an early-stage pick. Brand-level testing, not per-lot certified.

David Sinclair
Buy

Renue By Science NMN (liposomal, 500mg)

Limited ~$50

Of NMN brands with a genuine public per-batch COA, the most consistently cited as reputable. Caution: independent testing has found no detectable NMN in many marketplace listings, so verify the COA before buying.

Bryan Johnson, Mark Hyman, David Sinclair
Buy

Seed

Limited ~$50

Seed DS-01, a broad-spectrum multi-strain probiotic with a proprietary capsule-in-capsule delivery; no independent per-lot certification…

Called for in Brain & Mood Protocol
Mark Hyman
Buy

Antioxidant blend

Limited
Called for in Blueprint Daily Protocol
Bryan Johnson

Broad-spectrum probiotic

Limited
Called for in Functional Gut Reset
Mark Hyman

C8 MCT oil + grass-fed butter

Limited
Dave Asprey

Chasteberry

Limited
Called for in Hormone Balance Protocol
Sara Gottfried

Desiccated organ capsules

Limited
Called for in The Animal-Based Diet
Paul Saladino

DGL

Limited
Called for in Functional Gut Reset
Mark Hyman

Essential micronutrient capsules

Limited
Called for in Blueprint Daily Protocol
Bryan Johnson

Fisetin + quercetin

Limited
David Sinclair

High-sodium hydration mix

Limited
Stacy Sims

Juicer or high-speed blender

Limited
Anthony William (Medical Medium)

Ketone ester / salts / C8 MCT

Limited
Dom D'Agostino

L-glutamine + zinc + vitamin A

Limited
Mark Hyman

Longevity supplement blend

Limited
Called for in Blueprint Daily Protocol
Bryan Johnson

Methylated multivitamin

Limited
Called for in Superhuman Protocol
Gary Brecka

Mineral electrolytes / sea salt

Limited
Called for in Superhuman Protocol
Gary Brecka

Molecular hydrogen tablets

Limited
Called for in Superhuman Protocol
Gary Brecka

Mouth / nasal tape

Limited
Andy Galpin

Multi-form magnesium blend

Limited
Ben Greenfield

Multi-strain probiotic

Limited
Mark Hyman

NAC / glycine

Limited
Gary Brecka

NMN or NR

Limited
Called for in Blueprint Daily Protocol
Bryan Johnson

Quality coffee

Limited
Called for in The Biohacker's Morning
Dave Asprey

Third-party-tested moringa

Limited
Rhonda Patrick

Aged garlic extract

Citrulline

Curcumin

Grass-fed butter

K2

L-glutamine

Mineral sunscreen

Moisturiser

Piperine

Policosanol

SPF

Vitamin A

Vitamin C serum

Vitamin D3 & K2

Zinc

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