Longevity Supplement Stack
David Sinclair's morning stack targets NAD+ and sirtuin pathways using NMN, resveratrol, vitamin D and senolytics. It also includes physician-supervised prescription items; NMN reliably raises NAD+ in humans, but resveratrol's human longevity evidence is weak, and no supplement here has been shown to extend human lifespan. Diet, exercise and metabolic health remain the real foundation.
In his book Lifespan and in interviews, Sinclair has described a morning stack built around NAD+ and sirtuin pathways: NMN, resveratrol, vitamin D and senolytics, plus prescription items taken under medical care. Several pieces are scientifically contested, and he stresses it is personal and biomarker-guided, not a prescription. This page sells the legal OTC items and keeps prescription ones physician-only.
Why it worksâ–¼
NMN (NAD+ precursor)
Refuels NAD+, which declines with age; shown to raise NAD+ levels in humans.
Resveratrol with a fat source
Claimed sirtuin activator paired with NMN. Note: human evidence is contested.
Vitamin D3 and K2
Well-evidenced foundational micronutrients for bone, immune and metabolic health.
Diet, exercise, fasting and biomarker tracking
This is the part with the strongest evidence, and Sinclair says it underpins everything else.
Senolytics: fisetin and quercetin
Aim to clear senescent cells. Emerging area; human data is early.
Spermidine
Autophagy slows with age; spermidine is taken to support it. Limited human longevity data.
Berberine (he moved off metformin)
Targets AMPK and blood sugar. Berberine is OTC; metformin is prescription only.
Prescription items he has discussed
Listed only to describe his published approach. We do not sell or dose prescription drugs; never self-prescribe.
- Longevity-curious readers who want the real evidence picture
- People who already train, eat well and track biomarkers
- Biohackers comfortable with experimental compounds
- Conflict of interest: Sinclair has co-founded or advised companies with financial stakes in NAD+/sirtuin compounds (e.g. Metro International Biotech, Life Biosciences). Weigh his advocacy with that in mind
- Resveratrol and the NMN-resveratrol longevity claims are contested: independent labs have struggled to replicate key results and mouse-lifespan studies did not confirm benefits
- NMN: in late 2022 the FDA classified NMN as an investigational drug, so its status as a US dietary supplement is unsettled; it is widely sold as of 2026 but the situation is evolving. Treat this as publicly-described, not established
- Resveratrol's human evidence is weak and has been hard to replicate; some researchers prefer pterostilbene
- No supplement here is proven to extend human lifespan; treat the longevity compounds as experimental
- NMN's US regulatory status is unsettled (the FDA has called it an investigational drug); availability varies
- Metformin and statins are prescription, physician only; we do not sell or dose them. Berberine can lower blood sugar and interact with medications
- Consult a doctor or pharmacist and get bloodwork before starting; interactions are possible
- Educational only, not medical advice
- July 3, 2026 Protocol published.
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Not medical advice. This page is for education only and is not a substitute for professional medical care. Consult a qualified clinician before changing your health routine.
Independent curation. YourProtocol.ai is an independent platform. This protocol is based on the publicly available work of David Sinclair and is not created, reviewed, endorsed by, or affiliated with David Sinclair or Geneticist · Harvard.