Longevity Supplement Stack
David Sinclair's morning stack targets NAD+ and sirtuin pathways using NMN, resveratrol, vitamin D and senolytics. It also includes physician-supervised prescription items; NMN reliably raises NAD+ in humans, but resveratrol's human longevity evidence is weak, and no supplement here has been shown to extend human lifespan. Diet, exercise and metabolic health remain the real foundation.
NMN (NAD+ precursor) ~1 g in capsules with water (he later cited dropping to ~500 mg)
Refuels NAD+, which declines with age; shown to raise NAD+ levels in humans.
Resveratrol with a fat source ~1 g mixed into yogurt or with olive oil (fat improves absorption ~5x)
Claimed sirtuin activator paired with NMN. Note: human evidence is contested.
Vitamin D3 and K2 ~2,500+ IU vitamin D3 daily, with K2
Well-evidenced foundational micronutrients for bone, immune and metabolic health.
Diet, exercise, fasting and biomarker tracking Plant-rich diet, regular exercise, periodic fasting, routine bloodwork
This is the part with the strongest evidence, and Sinclair says it underpins everything else.
Senolytics: fisetin and quercetin ~500 mg fisetin, sometimes pulsed
Aim to clear senescent cells. Emerging area; human data is early.
Spermidine Supports autophagy
Autophagy slows with age; spermidine is taken to support it. Limited human longevity data.
Berberine (he moved off metformin) As of 2025 he largely switched from metformin to berberine for stomach tolerance
Targets AMPK and blood sugar. Berberine is OTC; metformin is prescription only.
Prescription items he has discussed His stack has at times included metformin, a statin and low-dose aspirin, under medical care. Prescription items are physician only.
Listed only to describe his published approach. We do not sell or dose prescription drugs; never self-prescribe.
This protocol works from your actual levels. Testing partner coming soon.
- Biological-age test
We may earn a referral fee if you book testing through a future partner link; it will never affect which tests are listed here. This is not medical advice or a diagnosis.
The thesis: NMN refuels NAD+ that declines with age, while resveratrol activates sirtuins that protect the genome.
View sources
Lifespan with Dr. David Sinclair, Ep 4: NMN, NR, Resveratrol, Metformin & Other Longevity Molecules
NMN, NR, Resveratrol, Metformin & Other Longevity Molecules (Lifespan with Dr. David Sinclair, Ep 4)
David Sinclair on switching from metformin to berberine (Moonshots with Peter Diamandis, 2025)
State of the evidence on NMN & resveratrol (NOVOS Labs, a supplement company that sells competing products; David Sinclair is not affiliated with NOVOS)
Not medical advice. This page is for education only and is not a substitute for professional medical care. Consult a qualified clinician before changing your health routine.
Independent curation. YourProtocol is an independent platform. This protocol is based on the publicly available work of David Sinclair and is not created, reviewed, endorsed by, or affiliated with David Sinclair or Geneticist · Harvard.
Is this for you
- Longevity-curious readers who want the real evidence picture
- People who already train, eat well and track biomarkers
- Biohackers comfortable with experimental compounds
Cautions
- Conflict of interest: Sinclair has co-founded or advised companies with financial stakes in NAD+/sirtuin compounds (e.g. Metro International Biotech, Life Biosciences). Weigh his advocacy with that in mind
- Sinclair's own published affiliations list includes past engagements with Elysium Health (a NAD+/NR supplement company he holds a licensed patent with) and Tally Health (a biological-age testing company he co-founded). Neither is sold on this page, but weigh these alongside his other disclosed interests (Metro International Biotech, Life Biosciences) when reading his advocacy.
- Resveratrol and the NMN-resveratrol longevity claims are contested: independent labs have struggled to replicate key results and mouse-lifespan studies did not confirm benefits
- NMN: in September 2025 the FDA reversed its 2022 position and confirmed NMN is not excluded from the dietary-supplement definition, though litigation risk and compliance obligations remain, so treat the situation as improved but not fully settled
- Resveratrol's human evidence is weak and has been hard to replicate; some researchers prefer pterostilbene
- No supplement here is proven to extend human lifespan; treat the longevity compounds as experimental
- NMN's US regulatory status improved in September 2025 after an FDA reversal, but litigation risk and compliance obligations remain; availability varies
- Metformin and statins are prescription, physician only; we do not sell or dose them. Berberine can lower blood sugar and interact with medications
- Consult a doctor or pharmacist and get bloodwork before starting; interactions are possible
- Educational only, not medical advice
⚠ Of NMN brands with a genuine public per-batch COA, the most consistently cited as reputable. Caution: independent testing has found no detectable NMN in many marketplace listings, so verify the COA before buying.
Some links earn us a commission. It never affects our picks or grades. See our affiliate disclosure.