Ketogenic Metabolic Protocol
Shift your fuel system toward ketones with a well-formulated approach, and understand exactly when ketosis is useful and when it is not.
D'Agostino studies metabolic therapies. A well-formulated ketogenic diet is very low carb, adequate protein and high fat, weighted toward mono-unsaturated fats and MCTs rather than the old very-high-saturated-fat clinical version. Electrolytes are not optional: most early 'keto flu' is sodium and water loss. Exogenous ketones (BHB salts) and MCT oil can raise ketones quickly and ease the transition, but he is candid that they are not for blind daily megadosing. You can measure the whole thing at home with a blood ketone meter.
Why it works▼
Go very low carb, adequate protein, high fat
This is what triggers and sustains nutritional ketosis.
Replace electrolytes generously
Lower insulin makes you excrete sodium and water; this prevents most keto flu.
Add MCT oil or powder
Raises ketones and crosses the blood-brain barrier; build up slowly to avoid GI upset.
Use exogenous ketones to ease in
Useful for the transition or a mental-energy boost; he cautions against high daily doses.
Track blood ketones at home
The diet's big advantage: you can verify you are actually in range.
Protein, quality fats, and micronutrients
Keeps the diet sustainable and nutritionally complete.
- Metabolic experimenters
- People seeking steady energy and focus
- Those who have stalled on other approaches
- Anyone who likes measurable feedback
- Type 1 diabetes, pregnancy, liver disease, or a history of kidney stones: do not attempt without medical supervision
- D'Agostino reported elevated liver enzymes after high-dose ketone supplementation, and high ketones can drop blood glucose too low; do not megadose
- Therapeutic uses (epilepsy, cancer, brain injury) are his research area, not health claims we make; these belong with a physician
- Stay well hydrated with electrolytes to protect the kidneys
- Educational only, not medical advice
- July 3, 2026 Protocol published.
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Not medical advice. This page is for education only and is not a substitute for professional medical care. Consult a qualified clinician before changing your health routine.
Independent curation. YourProtocol.ai is an independent platform. This protocol is based on the publicly available work of Dom D'Agostino and is not created, reviewed, endorsed by, or affiliated with Dom D'Agostino or Neuroscientist · University of South Florida.