Autoimmune Gut-Support Protocol (5R Framework)
Dr. Mark Hyman's 5R gut-repair framework applied to autoimmune support (remove, replace, reinoculate, repair, rebalance), as a complement to standard rheumatology or specialist care, not a cure.
Eliminate common inflammatory triggers (gluten, dairy, ultra-processed food) for a defined trial, then reintroduce one at a time Trial period
Identify individual triggers.
Add digestive enzyme support with meals if needed With meals
Supports digestion during repair.
Eat colorful polyphenol-rich plants plus a multi-strain probiotic and fermented foods Daily
Supports a diverse microbiome.
Support the gut barrier with glutamine, zinc and vitamin A Per guidance
Nutrients involved in intestinal barrier integrity.
Manage stress (meditation, breathwork) and protect sleep Ongoing
Supports the parasympathetic nervous system and gut-immune axis.
Use this alongside, never instead of, your specialist's care Ongoing
This does not reverse or cure autoimmune disease.
Gut-immune crosstalk is real and cited: intestinal barrier dysfunction (leaky gut) is associated with several autoimmune conditions in published immunology reviews.
View sources
The 5R Protocol - The Dr. Hyman Show #1038 (with Dr. Elizabeth Boham & Raja Dhir)
The Dr. Hyman Show #1038 show notes
Partners in Leaky Gut Syndrome: Intestinal Dysbiosis and Autoimmunity
Not medical advice. This page is for education only and is not a substitute for professional medical care. Consult a qualified clinician before changing your health routine.
Independent curation. YourProtocol is an independent platform. This protocol is based on the publicly available work of Mark Hyman and is not created, reviewed, endorsed by, or affiliated with Mark Hyman or Functional Medicine Physician · The Doctor's Farmacy.
Is this for you
- People with autoimmune conditions wanting gut-health support alongside specialist care
- Anyone interested in the evidence-honest version of the gut-immune connection
- Not a treatment or a way to reverse autoimmune disease
Cautions
- This is informational gut-health support alongside, never instead of, care from a rheumatologist or your treating specialist; it is not a treatment and does not reverse or cure autoimmune disease
- Do not stop, taper or change any immunosuppressant or disease-modifying medication based on this content; that decision belongs to your specialist
- Supplements and lab testing Dr. Hyman references may be available through businesses he has a commercial interest in
- If you have a diagnosed autoimmune condition, work with your care team before starting any elimination diet
- Gut-immune crosstalk is a real area of research; claims that fixing the gut alone reverses autoimmune disease go beyond current evidence
- Educational only, not medical advice
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