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Endurance & VO2 Max

Andy Galpin's cardio framework: train your Zone 2 base and your VO2 max as two separate things, on separate days, because they build different machinery. One of each per week goes a long way.

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Exercise scientist
Not endorsed · Based on the published work of Andy Galpin
Daily time
Weekly
Steps
6
Difficulty
Intermediate
Sources
2
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What it is

Galpin breaks fitness into nine distinct adaptations, and the endurance side is where most people train sloppily. His key correction: Zone 2 base work and VO2 max work are different adaptations and should be trained separately. Blend them into one undifferentiated 'cardio' session and you develop neither fully. The good news is the weekly dose is small.

Why it works
Zone 2 (easy, conversational effort) builds mitochondrial density and fat-burning efficiency, the aerobic base. VO2 max work (short, very hard intervals) raises your ceiling for oxygen delivery and use, which is one of the strongest predictors of long-term health. They rely on different cellular adaptations, so training them on different days with the right intensity is what makes each one actually improve. Progressive overload still applies: you have to nudge the stimulus up over time.
The evidence
Sources
Published work by Andy Galpin, cited straight to the source: long-form episodes, clips, peer-reviewed papers and their own writing. Select any to view it here.
1
Huberman Lab + Galpin: how to build strength, muscle size & endurance
Article
2
Andy Galpin's documented training framework
Article
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The protocol
Clinical strong human trials Mixed some or emerging evidence Commercial weak or unproven, sold widely Equipment / Test not an evidence claim How we grade →
Principle

Separate Zone 2 from VO2 max

Different days, different intensities

Combining them into one moderate 'cardio' slog gives you neither adaptation. Keep easy days truly easy and hard days truly hard.

Andy Galpin
For this step
No product needed
Base

Build a Zone 2 base

1 to 2 sessions/week, 30 to 60+ min at a conversational pace

Easy aerobic work you could hold a conversation through. A heart-rate monitor keeps you honest, since most people go too hard on easy days.

Andy Galpin
For this stepEquipment
Heart-rate chest strap monitor
Keeps easy days truly easy
Ceiling

Push VO2 max once a week

1 hard session: e.g. Norwegian 4x4 (4 min hard / 3 min easy x4)

One quality high-intensity session weekly raises your VO2 max. Use a bike, rower or treadmill so you can push hard safely.

Andy Galpin
For this stepEquipment
Rowing machine
Hard intervals with low joint impact; a bike or hills also work
Progress

Apply progressive overload

Add time, distance or intensity over weeks

Adaptation is a response to stress. Nudge the stimulus up gradually rather than doing the identical session forever.

Andy Galpin
For this step
No product needed
Fuel

Fuel the longer, harder sessions

Carbs for long/intense work (up to ~60g/hour if needed)

Short or easy sessions need little fuel. For long or glycogen-depleting work, carbohydrate during the session protects performance.

Andy Galpin
For this step
No product needed
Optional

Beta-alanine for high-intensity buffering

As a daily supplement if you do a lot of anaerobic work

Beta-alanine buffers the acid build-up of hard, 1 to 4 minute efforts. Useful if your training skews toward high-intensity intervals.

Andy Galpin
For this stepMixed
Beta-alanine
For repeated hard efforts; a harmless tingle is normal
Is this for you?
Good fit if
  • Lifters who neglect their heart and VO2 max
  • Anyone confused about Zone 2 vs intervals
  • People short on time who want the minimum effective cardio dose
  • Longevity-minded trainees (VO2 max is a strong health marker)
Cautions
  • If you have a heart condition, are new to exercise, or are pregnant, get medical clearance before high-intensity interval work.
  • True VO2 max efforts are very hard; build a base first and progress gradually to avoid injury.
  • Beta-alanine commonly causes a harmless skin tingle; split doses if it bothers you.
  • We may earn a commission on equipment bought through this page; brisk walks, hills and bodyweight intervals cost nothing.
  • We may earn a commission on products bought through this page; these can also be bought elsewhere.
Related protocols
Update history
  • July 3, 2026 Protocol published.
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Not medical advice. This page is for education only and is not a substitute for professional medical care. Consult a qualified clinician before changing your health routine.
Independent curation. YourProtocol.ai is an independent platform. This protocol is based on the publicly available work of Andy Galpin and is not created, reviewed, endorsed by, or affiliated with Andy Galpin or Exercise scientist.

Endurance & VO2 Max
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