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Functional Medicine Physician · The Doctor's Farmacy

Mark Hyman

New protocols and grade changes land in My Protocols.

Mark Hyman is a functional medicine physician, host of The Doctor's Farmacy podcast, and co-founder and chief medical officer of Function Health, known for arguing that most chronic disease traces back to a handful of root causes: blood sugar dysregulation, chronic inflammation, gut dysfunction, and a diet built on ultra-processed food. He founded the Cleveland Clinic Center for Functional Medicine and directs the UltraWellness Center, and he popularized the Pegan diet, a hybrid of paleo and vegan principles built around whole foods, healthy fats, protein and vegetables, and minimal sugar or refined carbohydrates. His core recommendations are food-first: eliminate ultra-processed food, prioritize protein and fiber, and stabilize blood sugar, with a smaller supplement layer (vitamin D, omega-3, magnesium, a multivitamin) added on top rather than substituted for diet. Through Function Health, he pushes routine lab testing so people can see their own biomarkers instead of guessing. YourProtocol covers the specific, evidence-graded protocols behind his approach below.

Beyond the protocols
Common questions about Mark
What supplements does Mark Hyman take?▾
His approach is food-first: diet is the primary intervention, with a smaller supplement layer on top, typically vitamin D, omega-3, magnesium and a multivitamin, adjusted to a person's own lab results rather than a fixed list for everyone. See our graded protocols below for specifics.
What is the Pegan diet?▾
The Pegan diet is Mark Hyman's hybrid of paleo and vegan principles: whole foods, quality protein and fat, and abundant vegetables, while minimizing sugar, refined grains and processed food. It is a framework for eating, not a fixed macro ratio or meal plan.
What is Mark Hyman known for?▾
He is a functional medicine physician, founder of the Cleveland Clinic Center for Functional Medicine, and co-founder and chief medical officer of Function Health, an at-home lab-testing company. He hosts The Doctor's Farmacy podcast and argues that blood sugar, inflammation and gut health drive most chronic disease.
Is Mark Hyman a real doctor?▾
Yes. He is a board-certified family physician (MD) who has practiced functional medicine for decades and founded the Cleveland Clinic's functional medicine center. His public recommendations are general information, not a substitute for personalized medical care.
Does Mark Hyman recommend testing before supplementing?▾
Yes, this is central to his approach. Through Function Health he pushes for routine blood-panel testing so people can adjust diet and supplements based on their own measured biomarkers rather than a generic, one-size-fits-all recommendation.

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